Role of circular RNAs in colorectal tumor microenvironment

Circular RNAs (circRNAs) are a class of endogenous noncoding RNA, which were previously considered as byproduct RNA splicing error. Numerous studies have demonstrated the altered expression circRNAs in organ tissues during pathological conditions and their involvements disease pathogenesis progression, including cancers. In colorectal cancer (CRC), multiple been identified characterized “oncogenic”, given downregulation tumor suppressor genes induction initiation, invasion, metastasis. Additionally, other CRC “tumor suppressive” based on ability inhibiting oncogenic suppressing growth proliferation. could serve potential diagnostic prognostic biomarkers, therapeutic targets or vectors to be utilized therapies. This review briefly describes dynamic changes microenvironment inducing immunosuppression tumorigenesis, outlines biogenesis characteristics recent findings indicating roles functions microenvironment. It also discusses strategies technologies, employed future overcome current therapy challenges associated with circRNAs.